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Non-Hodgkin’s Lymphoma (NHL) is a type of cancer that starts in the lymphatic system, which is part of the body’s immune system. The lymphatic system includes the lymph nodes, spleen, thymus, bone marrow, and lymphatic vessels—all of which help fight infections and maintain fluid balance.
In Non-Hodgkin’s Lymphoma, abnormal white blood cells (called lymphocytes) grow uncontrollably and accumulate in the lymph nodes or other parts of the body. These abnormal cells crowd out healthy cells, affecting the body’s ability to fight infection.
NHL includes many subtypes, which are usually classified based on how fast they grow and which type of lymphocyte is affected:
Examples: Diffuse large B-cell lymphoma (DLBCL), Follicular lymphoma, Mantle cell lymphoma
Examples: Peripheral T-cell lymphoma, Anaplastic large cell lymphoma
Non-Hodgkin’s Lymphoma (NHL) is a type of cancer that starts in the lymphatic system, which is part of the body’s immune system. The lymphatic system includes the lymph nodes, spleen, thymus, bone marrow, and lymphatic vessels—all of which help fight infections and maintain fluid balance.
In Non-Hodgkin’s Lymphoma, abnormal white blood cells (called lymphocytes) grow uncontrollably and accumulate in the lymph nodes or other parts of the body. These abnormal cells crowd out healthy cells, affecting the body’s ability to fight infection.
Painless swelling in the lymph nodes (neck, armpit, or groin)
Persistent fatigue or weakness
Fever and night sweats
Unexplained weight loss
Shortness of breath or chest pain (if lymph nodes press on the chest)
Abdominal pain or swelling
The exact cause is often unknown, but risk factors may include:
Weakened immune system (HIV/AIDS, organ transplant, autoimmune diseases)
Certain infections (e.g., Epstein-Barr virus, H. pylori)
Exposure to chemicals or radiation
Family history of lymphoma
Older age (risk increases with age)
Diagnosis typically involves:
Physical examination and medical history
Blood tests
Biopsy of lymph node or affected tissue
Imaging tests (CT, PET, or MRI scans)
Bone marrow examination (in some cases)
Treatment depends on the type and stage of NHL but may include:
Chemotherapy
Radiation therapy
Targeted therapy (e.g., rituximab)
Immunotherapy
Stem cell or bone marrow transplant
CAR-T cell therapy (for certain aggressive types)
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